NisinZ® P

Ultrapure Nisin Z

Model NO.: 2312
  • Introduction
  • Features
  • Applications
  • Regulations

NisinZ® Vegetal Nisin Z is a mixture of closely related antimicrobial polypeptides produced by strains of Lactococcus lactis subsp. Lactis. Recognized internationally as a well-defined, highly effective food antimicrobial agent with low toxicity and a well-established history of safe use. Over the past few decades, Nisin Z is FDA approved and generally regarded as a safe peptide with recognized potential for clinical use. Studies have reported that Nisin Z can prevent the growth of drug-resistant bacterial strains, such as methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Enterococci and Clostridium difficile.  Nisin Z has anti-biofilm properties and can work synergistically in combination with conventional therapeutic drugs. In addition, like host-defense peptides, Nisin Z may activate the adaptive immune response and have an immunomodulatory role.  Increasing evidence indicates that Nisin Z can influence the growth of tumors and exhibit selective cytotoxicity towards cancer cells.

At Handary, we provided NisinZ® Vegetal Nisin Z as an active antibacterial ingredient for therapeutic improvement and preservation in health care products. 

 

Description

NisinZ® P is an ultrapure Nisin Z concentration powder, produced by fermentation by the bacterium Lactococcus lactis obtained from sauerkraut. It is used as an active antibacterial ingredient for therapeutic improvement and preservation in health care products.

Key Benefits

- Active antimicrobial ingredients and Preservation

- Prevent the growth of Staphylococcus, Streptococcus, Enterococci and Clostridium

- Natural, friendly labeling

Applications areas

Skin infections, Respiratory Infections, Mastitis, Cancer, Oral health

Activity

Hydrous potency (IU/mg)

≥38,000

Composition

Nisin Z concentration (w/w)                 

≥95%

Moisture(w/w)

≤5%

Heavy metals

Lead (mg/kg)

<1

Arsenic(mg/kg)

<1

Mercury(mg/kg)

<1

Physical Specifications

Appearance

Off- white powder

 

Particle size

200mesh≥90%

Packaging

NisinZ® P is available in 10g or 100gr/bottle with integral, tamper-proof seals.

Storage Conditions

36 months, store unopened below 20°C in dry conditions, away from direct sunlight and odorous products. When opened, store at approx. 20°C in original container.

Regulation

CAS#: 1414-45-5 (US FDA), E#: E234 (EU EFSA), INECS/ELINCS #: 215-807-5

GMO Status

According to regulations (EC) no. 1829/2003. Microorganisms used for the production of this product are not genetically modified.

Country of origin

Belgium

Allergens

Components

Y/N

 Peanut or its derivatives

N

 Tree Nuts, macadamia nuts, pecans, pine nuts, pistachios and walnuts or their derivatives

N

 Sesame or its derivatives

N

 Eggs or its derivatives

N

 Fish or its derivatives

N

 Crustaceans and shellfish or their derivative

N

 Soy or its derivatives

N

 Wheat, triticale or their derivatives

N

 Mustard or its derivatives

N

 Milk or its derivatives (e.g. Lactose)

N

 Sulphites

N

Products

Applications

Functionalities

References

NisinZ®

Infections associated with drug-resistant pathogens

Anti- Staphylococcus aureus, Streptococcus pneumoniae, Enterococci and Clostridium difficile

Severina et al. (1998); Piper et al. (2009; Okuda et al. (2013);

Skin and soft tissue infections

Anti-S. aureus

Heunis et al. (2013)

Mastitis

Anti-Staphylococcal mastitis

Fernandez et al. (2008)

Cancer

Reduced HNSCC tumorigenesis

Joo et al. (2012); Kamarajan et al. (2015); Global Medical Discovery, (2015)

Oral health

Anti- streptococci, Streptococcus

Mutans, Cl. albicans

Le Lay et al. (2008); Tong et al. (2010); Najjar et al. (2009); Tong et al. (2014)

Nisin is a natural antimicrobial with GRAS status widely approved for use by the FDA for multiple applications. Always be sure to contact local authorities for novel health and personal care products.

PRODUCT RANGE
R5™ Antimicrobial effect validators
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